Organic Process Research and Development p. 1383 - 1387 (2017)
Update date:2022-08-11
Topics:
Zhu, Dianhu
Hong, Xin
Li, Dezhi
Lu, Long
Shen, Qilong
A new method for the 100 g scale synthesis of N-difluoromethylthiophthalimide 1 from cheap commodity chemical benzyl mercaptan and HCF2Cl or other difluorocarbene precursors was described. Reagent 1 is an excellent electrophilic difluoromethylthiolating reagent as demonstrated by the gram-scale synthesis of five difluoromethylthiolated derivatives of structurally complicated drug-like molecules and natural products.
View MoreYingkou Sanzheng Organic Chemical Co. Ltd.
Contact:+86-417-3638818
Address:25 Gengxinli Village, Daqing Road, Yingkou, Liaoning, China
Shanghai Haoyuan Chemexpress Co., Ltd.
Contact:86-21-51870955;58998985;58999585
Address:Room 601, No. 2 BLD, NO. 720, Cailun Road, Zhangjiang, Shanghai, China
Luojiang Chenming Biological Products Co
Contact:+86 15000297032
Address:GROUP NO.4, HE SHENG VILLAGE, PANLONG TOWN,
Contact:86-0510-85133006
Address:hubin road NO157
Tianjin Crest Pharmaceutical R&D Co., Ltd. (Tianjin Yao Technology Development Co., Ltd.)
Contact:+86-22-66211386
Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
Doi:10.1039/c39900000246
(1990)Doi:10.1016/j.molstruc.2006.11.026
(2007)Doi:10.1021/jo00381a052
(1987)Doi:10.1016/S0040-4020(01)99076-3
(1966)Doi:10.1134/S1070363208050307
(2008)Doi:10.1055/s-1984-30946
(1984)