Journal of Molecular Structure (2020)
Update date:2022-08-11
Topics:
Asha, R. Nandini
Bhuvanesh, N.
Daisy, Caroline
Kumar, G. S. Suresh
Nayagam, B. Ravindran Durai
Vadivel, E.
Biologically important 2-(2,4,6-trimethylbenzylthio)benzo[d]thiazole[BTM1] and 2-(4-((benzo[d]thiazol-2-ylthio)methyl)-2,3,5,6-tetramethylbenzylthio)benzo[d]thiazole [BTD2] were synthesized and characterised using FT-IR, NMR and single-crystal XRD (SCXRD). SCXRD revealed that both compounds were crystallized as a triclinic system and were associated through weak intermolecular interactions like H-bondings (CH…N, sp3-, and sp2-CH…π), π-π stackings and Vander Waals interactions. These weak intermolecular interactions in BTM1 and BTD2 were studied using Crystal Explorer and Gaussian. The interaction of title compounds with epidermal growth factor receptor (EGFR)tyrosine kinase protein was performed using AutoDock Vina. Molecular docking study revealed an efficient interaction of compounds with the protein resulting in good anti-cancer activity. DNA binding studies were explored against calf thymus (CT) DNA using a spectrophotometric titration method and was found that benzothiazole compounds showed hyperchromism and good binding efficiency. In-vitro anti-microbial activities against some bacterial and fungal strains were investigated. BTM1exhibited a better inhibition against bacterial (Bacillus subtilis and Staphylococcus aureus) and fungal (Aspergillus niger) strains than BTD2.
View MoreHubei Sibo Technology Co.,Ltd.
Contact:0715-6597222
Address:Pan Jia Wan fan Lake Chemical Industrial Park ,Xianning City, Hubei, China
Contact:0512-63006287
Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
Beyond Pharmaceutical Co., Ltd
Contact:+86-571-8195-3185
Address:No. 13-1, Liansheng Road, Yuhang District
Contact:+852-8198 2399
Address:9E, Leapont Industrial Building, 18-28 Wo Liu Hang Road, Shatin, New Territories, Hong Kong
Yangzhou Zhongbao Pharmaceutical Co.,Ltd
Contact:+86-514-88290838
Address:Jiangsu Baoying county economic develpment zone in baoying avenue91
Doi:10.1002/ejoc.201301026
(2013)Doi:10.1016/S0040-4039(02)01558-7
(2002)Doi:10.1016/j.poly.2013.06.031
(2013)Doi:10.1002/ejic.201100313
(2011)Doi:10.1039/jr9470000713
(1947)Doi:10.1002/anie.201411808
(2015)