Communication
ChemComm
theragnosis (e.g., heavy-atom-free photosensitizers).14 On the
other hand, the workability of a simple structural moiety, a
linear ethyl-ester chain, acting as a biological vector helping
the probe to accumulate into LDs, likely by mimicking the
remaining fatty-acid present in many lipids is demonstrated.14
In this context, some of the herein reported BODIPY esters
outstand as excellent fluorescent probes for LDs, their behaviour
successfully competing with well-established LD probes.11
Financial support from MINECO (CTQ2016-78454-C2-2-R,
MAT2017-83856-C3-1-P and MAT2017-83856-C3-2-P) and Comunidad
de Madrid (S2013/MIT-2850) is acknowledged. A. T. thanks UAM
for a pre-doctoral contract. F. G.-G. and A. P.-C. thank Comunidad
de Madrid/UCM for their respective research contracts.
Photobiological Sciences, ed. S. Nonell and C. Flors, RSC, London,
2016, vol. 13 and references cited therein.
6 For example, see: (a) H. He, D.-W. Li, L.-Y. Yang, L. Fu, X.-J. Zhu, W.-K.
Wong, F.-L. Jiang and Y. Liu, Sci. Rep., 2015, 5, 13543; (b) S. Liu, X. Tan,
S. Fang, Y. Wang, T. Liu, X. Wang, Y. Yuan, H. Sun, Q. Qi and C. Shi,
Adv. Funct. Mater., 2016, 26, 2826–2835; (c) C. Zhang, L. Long and
C. Shi, Adv. Ther., 2018, 1, 1800069(22 pages); (d) M. Li, S. Long,
Y. Kang, L. Guo, J. Wang, J. Fan, J. Du and X. Peng, J. Am. Chem. Soc.,
2018, 140, 15820–15826; (e) P. Gao, W. Pan, N. Li and B. Tang, Chem.
Sci., 2019, 10, 6035–6071.
7 (a) A. Meyers, T. M. Weiskittel and P. Dalhaimer, Lipids, 2017, 52,
465–475; (b) A. R. Thiam and M. Beller, J. Cell Sci., 2017, 130,
315–324.
8 Selected reviews: (a) J. Zhao, K. Xu, W. Yang, Z. Wang and F. Zhong,
Chem. Soc. Rev., 2015, 44, 8904–8939; (b) Y. S. Marfin, A. V.
Solomonov, A. S. Timin and E. V. Rumyantsev, Curr. Med. Chem.,
2017, 24, 2745–2772; (c) A. Turksoy, D. Yildiz and E. U. Akkaya,
Coord. Chem. Rev., 2019, 379, 47–64.
9 For example, see: N. Boens, B. Verbelen, M. J. Ortiz, J. Lijuan and
W. Dehaen, Coord. Chem. Rev., 2019, 399, 213024, DOI: 10.1016/
j.ccr.2019.213024 and references cited therein.
Conflicts of interest
10 (a) E. E. Spangenburg, S. J. P. Pratt, L. M. Wohlers and R. M.
Lovering, J. Biomed. Biotechnol., 2011, 5983358(8 pages); (b) J. Rumin,
H. Bonnefonf, B. Saint-Jean, C. Rouxel, A. Sciandra, O. Bernard, J.-P.
Cadoret and G. Bougaran, Biotechnol. Biofuels, 2015, 8, 42(16 pages);
(c) T. K. Fam, A. S. Klymchenko and M. Collot, Materials, 2018,
11, 1768(19 pages).
11 For example, see: (a) H. J. Yang, C. L. Hsu, J. Y. Yang and W. Y. Yang,
PLoS One, 2012, 7, e32693; (b) Z. Wang, C. Gui, E. Zhao, J. Wang,
X. Li, A. Qin, Z. Zhao, Z. Yu and B. Z. Tang, ACS Appl. Mater.
Interfaces, 2016, 8, 10193–10200; (c) H. Appelqvist, K. Stranius,
There are no conflicts to declare.
Notes and references
1 Cancer Theranostics, ed. C. Xiaoyuan and W. Stephen, Elsevier,
Amsterdam, 2014.
2 For example, see: M. H. Lee, A. Sharma, M. J. Chang, J. Lee, S. Son,
J. L. Sessler, C. Kang and J. S. Kim, Chem. Soc. Rev., 2018, 47, 28–52
and references cited therein.
¨
3 For example, see: (a) Z. Zhou, J. Song, L. Nie and X. Chen, Chem. Soc.
Rev., 2016, 45, 6597–6626; (b) D. van Straten, V. Mashayekhi, H. S. de
Bruijn, S. Oliveira and D. J. Robinson, Cancers, 2017, 9, 19(54 pages);
(c) Imaging in Photodynamic Therapy, in Series in Cellular and
Clinical Imaging, ed. M. R. Hambling and Y. Huang, CRC Press,
Boca Raton, 2017; (d) A. Ferreira dos Santos, D. R. Quieroz de
Almeida, L. Ferreira Terra, M. S. Baptista and L. Labriola, J. Cancer
Metastasis Treat, 2019, 5, 25(20 pages).
K. Borgjesson, K. P. R. Nilsson and C. Dyrager, Bioconjugate Chem.,
2017, 28, 1363–1370; (d) M. Gao, H. Su, S. Li, Y. Lin, X. Ling, A. Qin
and B. Z. Tang, Chem. Commun., 2017, 53, 921–924; (e) M. Jiang,
X. Gu, J. W. Y. Lam, Y. Zhang, R. T. K. Kwok, K. S. Wong and
B. Z. Tang, Chem. Sci., 2017, 8, 5440–5446; ( f ) M. Gao, H. Su, Y. Lin,
X. Ling, S. Li, A. Qin and B. Z. Tang, Chem. Sci., 2017, 8, 1763–1768;
(g) M. Collot, T. K. Fam, P. Ashokkumar, O. Faklaris, T. Galli,
L. Danglot and A. S. Klymchenko, J. Am. Chem. Soc., 2018, 140,
5401–5411; (h) M. Becerra-Ruiz, V. Vargas, P. Jara, C. Tirapegui,
C. Carrasco, M. Nunez, N. Lezama, A. Galdamez and M. Vilches-
Herrera, Eur. J. Org. Chem., 2018, 4795–4801; (i) X. Zheng, W. Zhu,
F. Ni, H. Ai and C. Yang, Sens. Actuators, B, 2018, 255, 3148–3154;
( j) N. Zhao, C. Ma, W. Yang, W. Yin, J. Wei and N. Li, Chem.
Commun., 2019, 55, 8494–8497.
4 For example, see: (a) A. Kamkaew, S. H. Lim, H. B. Lee, L. V. Kiew,
L. Y. Chung and K. Burgess, Chem. Soc. Rev., 2013, 42, 77–88;
˜
´
´
´
(b) G. Duran-Sampedro, N. Epelde-Elezcano, V. Martınez-Martınez,
˜
I. Esnal, J. Banuelos, I. Garcia-Moreno, A. R. Agarrabeitia, S. de la
´
Moya, A. Tabero, A. Lazaro, A. Villanueva, M. J. Ortiz and I. Lopez
Arbeloa, Dyes Pigm., 2017, 142, 77–87; (c) E. Palao, R. Sola-Llano,
´
A. Tabero, H. Manzano, A. R. Agarrabeitia, A. Villanueva, I. Lopez- 12 S. V. Mulay, T. Yudhistira, M. Choi, Y. Kim, J. Kim, Y. J. Jang, S. Jon
´
´
Arbeloa, V. Martınez-Martınez and M. J. Ortiz, Chem. – Eur. J., 2017,
23, 10139–10147; (d) N. Epelde-Elezcano, E. Palao, H. Manzano, 13 H. Lu, J. Mack, Y. Yang and Z. Shen, Chem. Soc. Rev., 2014, 43,
and D. G. Churchill, Chem. – Asian J., 2016, 11, 3598–3605.
˜
A. Prieto-Castaneda, A. R. Agarrabeitia, A. Tabero, A. Villanueva,
4778–4823.
´
´
´
´
´
S. de la Moya, I. Lopez-Arbeloa, V. Martınez-Martınez and M. J. Ortiz, 14 M. J. Ortiz Garcıa, S. de la Moya Cerero, A. R. Rodrıguez Agarrabeitia,
´
˜
Chem. – Eur. J., 2017, 23, 4837–4848; (e) D. Wang, M. M. Suet Lee,
W. Xu, R. T. K. Kwok, J. W. Y. Lam and B. Z. Tang, Theranostics, 2018,
F. Garcıa Garrido, A. Prieto Castaneda, M. A. Villanueva Oroquieta and
A. Tabero Truchado, Spanish Pat., application P201900017, 2019.
8, 4925–4956; ( f ) L. Li, Y. Chen, W. Chen, Y. Tan, H. Chen and 15 For a qualitative comparison of the reported PDT activity with
´
J. Yin, Chin. Chem. Lett., 2019, 30, 1689–1703; (g) J. Jimenez,
that exhibited by excellent and/or related photosensitizers, see:
(a) J. Berlanda, T. Kiesslich, V. Engelhardt, B. Krammer and K. Plaetzer,
J. Photochem. Photobiol., B, 2010, 100, 173–180; (b) R. L. Watley,
S. G. Awuah, M. Bio, R. Cantu, H. B. Gobeze, V. N. Nesterov,
S. K. Das, F. D’Souza and Y. You, Chem. – Asian J., 2015, 10,
1335–1343.
´
R. Prieto-Montero, B. L. Maroro, F. M. Jimenez, M. J. Ortiz,
´
´
´
´
A. Oliden-Sanchez, I. Lopez-Arbeloa, V. Martınez-Martınez and S. de
la Moya Cerero, Chem. – Eur. J., 2019, DOI: 10.1002/chem.201904257.
5 For example, see: Singlet Oxygen. Applications in Biosciences and
Nanosciences, in Comprehensive Series in Photochemical and
Chem. Commun.
This journal is ©The Royal Society of Chemistry 2019