Natural Product Research p. 2925 - 2931 (2019)
Update date:2022-08-11
Topics:
Sun, Kai-Hui
Ma, Xin-Hua
Zeng, Xian-Ming
Lin, Zhong-Yue
Cai, Yu-Mei
Zhang, Hai-Tao
Lin, Xiao-Yan
Feng, Shi-Biao
Zhong, Tian-Hua
Zhang, Yong-Hong
One new indole-type alkaloid, α-L-rhamnopyranosyl-(1→6)-β-D- glucopyranosyl 6-methoxy-3-indolecarbonate (1), together with three known alkaloids (2–4), one aromatic acid (5) and five known saponins (6–10), was isolated from the roots of Clematis florida var. plena. Their structures were established by NMR spectroscopic analysis and acid hydrolysis. In in vivo anti-inflammatory activity, n-butanol extract was found to be potent against ear edema in mice, with inhibition rate of 48.7% at a dose of 800 mg/kg. Furthermore, compounds 8 and 9 obtained from the n-butanol extract exhibited significant anti-inflammatory activities with inhibition rates of 50.9% and 54.7% at a dose of 200 mg/kg.
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