Turkish Journal of Chemistry p. 157 - 171 (2019)
Update date:2022-08-16
Topics:
Dmochowska, Barbara
Pellowska-Januszek, Lucyna
Samaszko-Fiertek, Justyna
Slusarz, Rafal
Wakiec, Roland
Madaj, Janusz
Quaternary ammonium salts are a group of compounds with diverse biological properties, the most important of which are their antiviral, antibacterial, and antifungal activities. The quaternization reactions of 5'-O-tosyl derivatives of uridine and thymidine with triethylamine, trimethylamine, 4-(N,N-dimethylamino)pyridine, 2-methylpyridine, and pyridine are described in this article. Two of the synthesized compounds are exceptional because they are first of this type that demonstrate concentration-dependent antifungal in vitro activity against two species of the genus Candida in minimal YNB-SG medium. The experimental results have been extended by adding full atom molecular dynamics simulations and substrates and products energies evaluation.
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Doi:10.1021/ja00321a043
(1984)Doi:10.24820/ark.5550190.p010.477
(2018)Doi:10.1515/hc-2017-0187
(2018)Doi:10.1016/j.tetlet.2009.03.148
(2009)Doi:10.1039/c6md00688d
(2017)Doi:10.1021/ja01365a058
(1930)