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Dalton Transactions
lower cellular accumulation than the platinum(II) complex
2·Gd after 1.5 h. Complex 3·Gd was derivatised through
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that lanthanide complexes based on 1 have significant poten-
tial for development as cell-permeant probes. The cellular
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Author contributions
SF and NF and AB were responsible for conceptualization,
formal analysis, funding acquisition, methodology, project
administration, resources, supervision, visualization and
writing. KY carried out synthesis and characterisation, GK and
KY carried out diffusion NMR experiments. AH carried out the
biological experiments with assistance from KY. PH conducted
ICP-MS experiments. ALT and KEC solved the X-ray crystallo-
graphic structure.
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Conflicts of interest
20 C. J. Adams and T. J. Meade, Chem. Sci., 2020, 11, 2524.
21 G. Thiabaud, G. He, S. Sen, K. A. Shelton, W. B. Baze,
L. Segura, J. Alaniz, R. M. MacIas, G. Lyness, A. B. Watts,
H. M. Kim, H. Lee, M. Y. Cho, K. S. Hong, R. Finch,
Z. H. Siddik, J. F. Arambula and J. L. Sessler, Proc. Natl.
Acad. Sci. U. S. A., 2020, 117, 7021.
There are no conflicts to declare.
Acknowledgements
22 M. Delbianco, V. Sadovnikova, E. Bourrier, G. Mathis,
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This work was supported by the Wellcome Trust (201406/Z/16/
Z), Cancer Research UK (CR-UK) grant number C5255/A18085,
through the Cancer Research UK Oxford Centre, L’Oréal, the
John Fell Fund and the EPSRC (EP/S019901/1).
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O. A. Blackburn, A. M. Kenwright, P. D. Beer, S. Aldridge
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