European Journal of Medicinal Chemistry p. 426 - 435 (2019)
Update date:2022-08-29
Topics:
Zhai, Min'an
Liu, Shiyuan
Gao, Meiqi
Wang, Long
Sun, Jun
Du, Jianan
Guan, Qi
Bao, Kai
Zuo, Daiying
Wu, Yingliang
Zhang, Weige
A series of novel 3,5-diaryl-1H-pyrazolo[3,4-b]pyridines as tubulin polymerization inhibitors targeting the colchicine site were designed via ring tethering strategy, which was supported by conformational analysis. The general, chemically unstable and rot
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