Chemical Biology and Drug Design p. 1963 - 1971 (2018)
Update date:2022-08-10
Topics:
Huang, Limin
Wei, Di
Wu, Zibo
Hou, Yajing
Xie, Yitong
Liu, Zhenru
Wang, Cheng
Che, Delu
Lei, Yibo
He, Huaizhen
A fluorescent probe (Fluo-HMF) was developed via introduction of a furfural moiety into the fluorescein molecular skeleton, aiming at specially labeling cell membrane of mast cells. To illustrate its specificity, we designed and synthesized a series of fluorescent compounds based on fluorescein molecular skeleton. The fluorescent properties of Fluo-HMF were investigated, which were in accordance with theoretical calculations. Compared with other fluorescein derivatives, Fluo-HMF could specially label RBL-2H3 cells. The results suggested that Fluo-HMF could be used as a fluorescent probe for bioimaging on some related research of allergic mechanism.
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