Bioorganic and Medicinal Chemistry Letters p. 2279 - 2282 (1999)
Update date:2022-08-16
Topics:
Xu, Wei-Chu
Zhou, Qin
Ashendel, Curtis L.
Chang, Ching-Te
Chang, Ching-Jer
A series of β-substituted polythiophene derivatives was synthesized through palladium-catalyzed coupling reaction. Their structure-protein kinase C (PKC) inhibitory activity relationship was studied. The carboxaldehyde and hydroxymethyl derivatives of α-terthiophene were potent PKC inhibitors (IC50 = 10-7 M).
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