Jou Pr nl e aa ls oe fd Mo an to et r ai ad lj su s Ct hm ea mr g ii sn ts ry B
DOI: 10.1039/C6TB02040B
Journal Name
ARTICLE
released into the simulated gastric fluid (pH = 2). For the 9.
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7
sample MCM-41-pCA-N which was irradiated by UV light with
1
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a wavelength of 365 nm (closed pore configuration) no further
release was observed in the time interval 8-48 hours since
1
creation of cyclobutane rings. The total released from closed
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opened pore configuration and represented 48 % of total
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loaded amount of naproxen in acidic medium (Fig. 10a) and 60
in slightly alkaline medium (Fig. 10b).
2
%
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Conclusions
1
1
In this paper, a photo-responsive p-coumaric acid derivative
was prepared and subsequently grafted onto MCM-41 silica
nanoparticles to investigate a creation of photo-controlled
molecular gates using UV light. The photo-controlled pore
open/close mechanism is associated with the photo-
dimerization reaction at 365nm (closed pore configuration)
and its reversible photo-cleavage at 254 nm (opened pore
configuration). The pores of the silica have been successfully
filled by a non-steroidal antiinflammatory drug (NSAID),
naproxen. The amount of adsorbed naproxen was 399 mg per
gram of MCM-41-pCA-N sample. In the opened pore
configuration, 93 % of naproxen was released into a simulated
body fluid (pH=7.4) within 48 hours and 70 % was released
into the simulated gastric fluid (pH = 2). In the closed pore
configuration the released amount was lover and represented
1
1
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48 % of released naproxen in acidic medium and 60 % in
slightly alkaline medium. Obtained results clearly demonstrate
that the reversible photo-reaction of p-coumaric acid
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the controlled storage/release of drug molecules and the
release can be driven by UV light as physical stimulus.
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1
Acknowledgements
8
This work was supported by the Slovak Research and 31. Q. Cai, W.Y. Lin, F.S. Xiao, W.Q. Pang, X.H. Chen, B.S. Zou,
Development Agency under the contract APVV-15-0520. E.B.
thanks to support from VVGS-PF-2016-72609 grant. The
authors also wish to thank Dr. V. Girman from UPJŠ for TEM
measurements.
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