Tetrahedron Asymmetry p. 3303 - 3309 (2000)
Update date:2022-08-30
Topics:
Fadnavis, Nitin W.
Luke Babu, Ravi
Sheelu, Gurrala
Deshpande, Ashlesha
Lipase from Pseudomonas cepacia (Amano PS and PS Lipase, Fluka) immobilised in microemulsion-based organogels formed by gelatin solubilisation and crosslinking with glutaraldehyde ('Gelozyme') has been used for the alcoholysis of the butanoate ester of racemic 2-hydroxy-(3-phenoxy)phenylacetonitrile with 1-butanol in hexane to obtain (S)-2-hydroxy-(3-phenoxy)phenylacetonitrile. The immobilised enzyme can be used over 25 days (25 cycles) without significant loss of enzyme activity (<10%). Copyright (C) 2000 Elsevier Science Ltd.
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