Inorganica Chimica Acta p. 44 - 50 (2018)
Update date:2022-08-17
Topics:
You, Zhonglu
Yu, Huiyuan
Zheng, Boyang
Zhang, Chenglu
Lv, Chengwei
Li, Kun
Pan, Lin
Urease inhibitors can counteract the negative effects of urease. In this paper, three new copper(II) complexes derived from 3-methyl-N′-(pyridin-2-ylmethylene)benzohydrazide (HL) were prepared. They are [CuBr(CH3OH)L] (1), [Cu(CH3OH)L(NCS)] (2), and [CuL(HL)]·ClO4 (3). The complexes were characterized by infrared and UV–Vis spectra, and single crystal X-ray determination. The Cu atoms in complexes 1 and 2 display square pyramidal coordination, and in complex 3 the Cu atom displays octahedral coordination. Complex 1 shows effective urease inhibitory activity, with IC50 value of 1.46 ± 0.83 μM. Molecular docking study of the complexes with Jack bean urease was performed.
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Doi:10.1002/chem.201902812
(2019)Doi:10.1021/acs.jmedchem.8b01372
(2019)Doi:10.1139/v68-038
(1968)Doi:10.1039/b806042h
(2008)Doi:10.1016/j.molcata.2007.12.008
(2008)Doi:10.1107/S0567740872002985
(1972)