Bioscience, Biotechnology and Biochemistry p. 1771 - 1773 (1998)
Update date:2022-08-11
Topics:
Hayashi, Yoshiki
Nishikawa, Yasushi
Mori, Hirotaka
Matsushita, Yoh-ichi
Sugamoto, Kazuhiro
Matsui, Takanao
Both the S and R enantiomers of (E)-13-hydroxy-10-oxo-11-octadecenoic acid (1) and (E)-10-oxo-11-octadecen-13-olide (2) had similar IC50 values against P388 mouse leukemia cells; i.e. the stereochemistry of the asymmetric center of 1 and 2 had no influence on the cytotoxic activity. Bioassay results of various compounds related to 1 and 2 suggests that the 1O-oxo and lactone moieties of 2 were important for enhancing the cytotoxicity. - Keywords: corn; cytotoxicity; fatty acid; (E)-13-hydroxy-10-oxo-11octadecenoic acid; (E)-10-oxo-11-octadecen-13-olide.
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