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with a natural fusogenic lipid, DOPE and cholesterol in particular
molar ratios to form co-liposomes. We had then successfully
encapsulated an anticancer drug, doxorubicin, inside these co-
liposomes which exhibited excellent pH-induced release of the
payload. Importantly this pH-targeted drug delivery resulted in an
enhanced cellular internalization and induced cytotoxicity to the
DOX-resistant HeLa cancer cells in vitro. Such a system may
therefore be a potential tool to be used as a stimulus responsive,
biocompatible and serum stable nanovehicle in chemotherapeutic
treatments where drug resistance becomes a serious issue. We are
now exploring the therapeutic utility of this system, particularly in
the way of targeting specific tumor cells those have transformed
into multi drug resistant (MDR) forms. Furthermore, this pH-
targeted strategy may be used for the treatment of various
inflammations and infections which also have lower pH regime than
physiological pH values and thus preferential drug release could
also be tested in such areas. This newly designed pH-sensitive co-
liposomes would therefore add to the armory of new nanocarrier
systems promising improved chemotherapeutic treatments.
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‡ The authors wish to acknowledge the support received from
the Council of Scientific & Industrial Research (CSIR) through
“Advanced Drug Delivery” project and the Department of
Science and technology (DST) through Indo-Australian Strategic
Research Fund. This work was also supported by the DST-JC Bose
fellowship to SB. PM wishes to acknowledge DST for the
Technical Research Centre (Project No. AI/1/62/IACS/2015) at
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