F.R. Ferreira et al. / Electrochimica Acta 56 (2010) 797–803
803
concentration of MGN provided by the -CD complexation, a signal
appeared for H-4 at 6.5 ppm. These results indicate that the inclu-
sion of MGN in the CD cavity occurs through its aromatic group.
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4. Conclusions
This work involved an electrochemical study of MGN in the
presence of -CD, aiming to gain further insights on the solubility,
bioavailability, and reactivity of this biologically active molecule.
The inclusion complex between -CD and MGN was formed
with a stoichiometry of 1:1 and an apparent formation constant
KF 1.6 0.7 × 105 L mol−1 was obtained by spectrophotometry.
Electrochemical methods (direct and indirect) led to values of
1.3 0.3 × 104 L mol−1 and 1.7 0.8 × 104 L mol−1
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The different values obtained by spectrophotometry (higher) and
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penetrate the CD cavity on the gold electrode.
The use of the -CDCNT electrode enhanced the response
in voltammetric measurements of MGN. Therefore, the use of a
combination of host–guest interactions may be an advantageous
analytical strategy in the development of sensors. The inclusion
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Acknowledgements
The financial support of the Brazilian research funding agencies
CNPq, CAPES, FAPEAL, and specially CNPq/PROSUL 490673/2007-
4, and PRONEX/FAPEAL/CNPq, is gratefully acknowledged. The
authors also thank the reviewers of the present paper for their
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