6
N. J. MUTHIPEEDIKA ET AL.
(t, J ¼ 10.4 Hz, 1H), 4.22 (d, J ¼ 10.4 Hz, 1H), 5.29 (s, 2H), 6.37 (d, J ¼ 2.4 Hz, 1H), 6.46
(dd, J ¼ 2.4, 8.4 Hz, 1H), 7.01 (d, J ¼ 8.4 Hz, 1H), 7.06 (d, J ¼ 8.4 Hz, 2H), 7.29 (d,
J ¼ 8.8 Hz, 2H), 8.14 (s, 1H), 8.79 (s, 1H). 13C NMR (100 MHz, DMSO-d6): d ¼ 31.1,
32.3, 36.9, 55.0, 60.8, 70.1, 101.1, 106.8, 114.1, 114.9, 123.4, 128.4, 128.5, 130.2, 134.0,
136.1, 139.0, 143.2, 154.6, 156.8, 158.6. MS (EI): m/z (%) ¼ 462 (1) [M]þ, 137 (100).
Anal. Calcd for C23H22N6O5: C, 59.73; H, 4.80; N, 18.17. Found: C, 59.39; H, 4.45;
N, 17.88.
Conclusion
A facile and convenient methodology has been developed for the sequential one-pot
synthesis of 1-hetero(aryl)-1,2,3-triazoles linked with equol under mild conditions. The
reaction was found to be tolerant with a wide variety of heteroaryl azides which point
toward its broad scope and diversity. The protocol described here can be extended for
the synthesis of diverse triazole hybrids linked to other complex molecules in future.
The detailed experimental procedure and characterization data including spectra are
Funding
The authors are thankful to Russian Science Foundation [Grant # 18-13-00161].
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