Tetrahedron p. 5969 - 5978 (1991)
Update date:2022-08-17
Topics:
Hakamatsuka, Takashi
Hashim, Muhammed Faisal
Ebizuka, Yutaka
Sankawa, Ushio
The reaction mechanism of oxidative rearrangement in the conversion of liquiritigenin, a flavanone, into 2,7,4'-trihydroxyisoflavanone was studied in elicitor-challenged Pueraria lobata cell cultures.The involvement of cytochrome P-450 in the reaction, hydroxylation associated with 1,2-aryl migration, was proved previously by the inhibition experiments with carbon monoxide and P-450 inhibitors.In order to obtain rigorous evidence proving that the enzyme is a P-450, a reconstitution experiment was performed with solubilized cytochrome P-450 and NADPH:cytochrome P-450 reductase fractions.During these studies we noticed that various biosynthetic reactions can be interpreted as P-450-mediated reactions associated with migration or bond cleavage.Ring contraction of 7-hydroxy-kaurenoic acid in gibberellin biosynthesis, the formation of a furan ring in furanocoumarin biosynthesis and several rearrangement reactions in steroid metabolism are discussed as examples of P-450 reactions associated with migration or bond cleavage.
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Doi:10.1134/S1070363216080235
()Doi:10.1021/jacs.9b13173
(2020)Doi:10.3390/molecules181215344
(2013)Doi:10.1021/ja00217a020
(1988)Doi:10.1080/10426509808033731
(1998)Doi:10.1002/ps.2780440310
(1995)