Setareh Moghimi et al.
Table 3. Acetylcholinesterase inhibitory activities of Supplementary Information (SI)
a
compounds 5a–5j.
1
13
Full experimental details and H, C NMR spectra are
Entry
Compound
IC50 (μ M)
1
2
3
4
5
6
7
8
9
5a
5b
5c
5d
5e
5f
5g
5h
>25
1.88 ± 0.091
>25
Acknowledgements
3.97 ± 0.19
This study was funded and supported by Research
Council of Tehran University of Medical Sciences
(TUMS); Grant no. 93-03-45-29092 and Iran National
Science Foundation (INSF).
>25
>25
1.94 ± 0.077
5.85 ± 0.27
>25
>25
0.022 ± 0.002
5i
5j
10
1
1
Donepezil
References
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Data are expressed as Mean ± SE (three independent
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3.2 Biological activity
Acetylcholinesterase (AChE) is an important enzyme
responsible for the hydrolysis of acetylcholine. The
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5
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