Organic & Biomolecular Chemistry
Communication
terised by short reaction times, ambient temperature con-
ditions, and high reaction selectivities. The use of t-Bu2Mg, 2,
under a reverse addition protocol, delivered high reactivity in
the case of 4-substituted cyclohexanone substrates. In contrast,
Mes2Mg, 1, a less reactive base, allowed the formation of enol
phosphates from more sensitive ketones, bearing a variety of
functional units. The stability of the products, and the facile
process developed herein using carbon-centred bases 1 and 2,
enables the enol phosphate products to be utilised as more
readily accessible substrates for future synthetic challenges,
which we will report on in due course.
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Acknowledgements
We would like to thank the EPSRC and GlaxoSmithKline for
financial support, and the EPSRC Mass Spectrometry Service,
University of Wales, Swansea for analyses.
5 For examples where enol phosphates react with strong
lithium amide bases to give vinyl anions, which then
undergo
O-
to
C-phosphate
transfer,
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