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Functional supramolecular polymers for biomedical applications.
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copolymer conjugated with near infrared fluorescence probe for
imaging of intelligent drug delivery. ACS Applied Materials &
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Gao, W., Chan, J., & Farokhzad, O. (2010) pH-responsive nanoparti-
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Guo, R., Su, Q., Zhang, J., Dong, A., Lin, C., & Zhang, J. (2017) Fac-
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spectroscopy (Wu et al., 2014). The time course of varia-
tion of UV–vis adsorption at pH 2 is depicted in Fig. 5a. The
degradation of the acylhydrazone bond with time is
reflected by the decrease of the absorption at 328 nm,
which can also respond to the drug release rate (Fig. 5b). It
is obvious that about 80% drug molecules can be released
from the supramolecular aggregates within 120 min. Thus,
these supramolecular assemblies can act as a drug delivery
system, which can realize the controlled drug release by
tuning the releasing environment.
Guragain, S., Bastakoti, B., Malgras, V., Nakashima, K.,
&
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Chemistry—A European Journal, 21:13164–13174.
Conclusion
Haldar, U., Bauri, K., Li, R., Faust, R.,
& De, P. (2015)
Polyisobutylene-based pH-responsive self-healing polymeric gels.
ACS Applied Materials & Interfaces, 7:8779–8788.
Hu, M., Huang, P., Wang, Y., Su, Y., Zhou, L., Zhu, X., & Yan, D.
(2015) Synergistic combination chemotherapy of camptothecin and
floxuridine through self-assembly of amphiphilic drug−drug conju-
gate. Bioconjugate Chemistry, 26:2497–2506.
In summary, we successfully synthesized a cationic
surfactant (dodecyl[2-(4-formylphenoxy)ethyl] dimethy-
lammonium bromide [C12-CHO]) and constructed a supra-
amphiphile (C12-CHIM) by connecting the ionic surfactant
C12-CHO with the drug molecule IAH via a dynamic cova-
lent bond. The supra-amphiphile can hierarchically self-
assemble into stable micelles in alkaline buffered solutions,
which facilitated the drug delivery. Interestingly, after the
hydrolysis of the dynamic covalent bond in acidic environ-
ments, controlled drug release can be realized. Thus, this
work paves a way for the regulated drug delivery of a
supramolecular amphiphile-drug system.
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Supramolecular construction of multifluorescent gels: Interfacial
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2602–2663.
Acknowledgements This work was supported by the National Nat-
ural Science Foundation of China (nos. 21573132 and 21403151), the
National Basic Research Program (no. 2013CB834505), and the Natu-
ral Science Foundation for Young Scientists of Shanxi Province
(no. 2016021045).
Kang, Y., Cai, Z., Tang, X., Liu, K., Wang, G., & Zhang, X. (2016)
An amylase-responsive bolaform supra-amphiphile. ACS Applied
Materials & Interfaces, 8:4927–4933.
Kang, Y., Tang, X., Cai, Z., & Zhang, X. (2016) Supra-amphiphiles
for functional assemblies. Advanced Functional Materials, 26:
8920–8931.
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and reusable organocatalyst for direct asymmetric aldol reaction in
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