Journal of Antibiotics p. 38 - 44 (2000)
Update date:2022-08-11
Topics:
Sasaki, Toru
Nose, Hiroshi
Hosoya, Ayako
Yoshida, Shigemi
Kawaguchi, Mami
Watanabe, Takashi
Usui, Takayuki
Ohtsuka, Yasuo
Shomura, Takashi
Takano, Satoko
Tatsuta, Kuniaki
The structures of new antifungal antibiotics, PF1163A and B, were elucidated by spectroscopic analyses of the degradation products and by X-ray crystallography of the de-2-hydroxyethyl derivative of PF1163B. Both antibiotics consist:of a 13-membered macrocyclic structure containing a derivative of N-methyl tyrosine and a hydroxy fatty acid. PF1163A differs from PF1163B by having an additional hydroxyl group on the side chain.
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