Collection of Czechoslovak Chemical Communications p. 1327 - 1333 (2011)
Update date:2022-08-24
Topics:
Pierra, Claire
Counor, Clement
Storer, Richard
Gosselin, Gilles
An example of a 2'-C-methyl branched nucleoside analogue bearing 3,4-dihydro-3-oxopyrazine-2-carboxamide as the base, namely 4-(2-C-methyl- β-D-ribofuranosyl)-3-oxo-3,4-dihydropyrazine-2-carboxamide, is reported. This compound was synthesized following a Vorbrueggen's glycosylation procedure in a few steps. When evaluated in cell culture experiments against a broad range of viruses, this compound did not exhibit any significant antiviral effect or cytotoxicity.
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