542
Vol. 39
far as we could find, a new compound (Scheme 7). The
yields of both reaction steps are high and this procedure
can be a general alternative for the impractical direct
aminolysis in a bomb tube.
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[
3
[
Petersen, J. Org. Chem., 64, 6797 (1999).
Conclusion.
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Am. Chem. Soc., 121, 9550 (1999).
From all given examples on Suzuki, Stille and
Buchwald-Hartwig reactions, we can conclude that
palladium-catalyzed cross-coupling reactions on readily
available and cheap chlorinated pyridazines and 3(2H)-
pyridazinones are very efficient and generally applicable
for the synthesis of pyridazine derivatives, which are
sometimes hard to prepare via classical synthetic methods.
Other examples will follow soon.
[18] C. Zhang and M. L. Trudell, Tetrahedron Lett., 41, 595 (2000).
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[
Acknowledgements.
Heterocyclic Chem., 32, 1057 (1995).
We thank J. Aerts, W. Bollaert, J. Schrooten,
W. Van Dongen, W. Van Lierde, N. Verhaert and
J. Verreydt for technical assistance. Dr. B.U.W. Maes
thanks the Fund for Scientific Research (FWO-
Vlaanderen) for an appointment as a postdoctoral fellow.
Dr. Janez Ko s˘ mrlj thanks the ‘RUCA Algemeen Fonds
voor Onderzoek’ for a post-doctoral grant. We are
indebted to Prof. Dr. R. Dommisse and Prof. Dr. L. Pieters
for the use of their NMR facilities and to
Prof. Dr. E. Esmans for ESI-MS measurements.
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