Chemistry of Heterocyclic Compounds p. 33 - 35 (1988)
Update date:2022-08-29
Topics:
Perevalov, V. P.
Karim, A. K. Kh.
Khrapov, A. V.
Baryshnenkova, L. I.
Stepanov, B. I.
The bromination of 1,3,5-trimethyl-4-chloropyrazole with N-bromosuccinimide (NBS) in the presence of benzoyl peroxide leads to 5-bromomethyl-1,3-dimethyl-4-chloropyrazole, whereas 3,5-bis(bromomethyl)-1-methyl-4-chloropyrazole predominates in the case of a twofold excess of NBS.Products of subsequent substitution in the 3- and 5-bromomethyl groups of the 3,5-bis(bromomethyl) compound in a ratio of 3:1 were detected in small amounts; this is evidently associated with the syn orientation of the bromine atom in the 5-bromomethyl group, which hinders attack by the bromine radical.
View MoreContact:0512-63006287
Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
Suzhou Health Chemicals Co., Ltd.
website:http://www.healthchems.com
Contact:13776257979
Address:No. 338, Jingang Avenue,
Shanghai Hongbang Medical Technology CO.,. Ltd
Contact:13671516988 /18917636693
Address:Room1, No67 Building, Yongde Road369, Wujing Town, Minhang Districy, Shanghai CIty, China.
Xinchang Yueding Chemical Co., Ltd.
Contact:86-571-56926323
Address:NO.90 BEIMENCHENGWAI CHENGGUAN TOWN XINCHANG
Contact:(1) 206-3550089
Address:5115 NE 8TH PL, Renton, WA 98059 USA
Doi:10.1002/cplu.201300130
(2013)Doi:10.1016/0040-4039(95)01656-2
(1995)Doi:10.1021/acs.orglett.6b03267
(2016)Doi:10.1016/j.crci.2013.07.010
(2014)Doi:10.1016/0040-4039(95)80003-4
(1995)Doi:10.1002/hc.21174
(2014)