Molecules p. 9339 - 9353 (2014)
Update date:2022-08-10
Topics:
D'Errico, Stefano
Oliviero, Giorgia
Borbone, Nicola
Piccialli, Vincenzo
Pinto, Brunella
De Falco, Francesca
Maiuri, Maria Chiara
Carnuccio, Rosa
Costantino, Valeria
Nici, Fabrizia
Piccialli, Gennaro
The synthesis of four novel platinum complexes, bearing N6-(6- Aminohexyl) adenosine or a 1,6-di(adenosin-N6-yl)-hexane respectively, as ligands of monofunctional cisplatin or monochloro(ethylendiamine)platinum(II), is reported. The chemistry exploits the high affinity of the charged platinum centres towards the N7 position of the adenosine base system and a primary amine of an alkyl chain installed on the C6 position of the purine. The cytotoxic behaviour of the synthesized complexes has been studied in A549 adenocarcinomic human alveolar basal epithelial and MCF7 human breast adenocarcinomic cancer cell lines, in order to investigate their effects on cell viability and proliferation.
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