Carbohydrate Research p. 17 - 28 (1995)
Update date:2022-08-10
Topics:
Lankhorst, Peter P.
Smeets, Jan W.H.
Haasnoot, Cornelis A.G.
The two glycosides (S)-heterodendrin and (R)-epi-heterodendrin were synthesized in a novel, one-step enzymatic synthesis, and separated by means of column chromatography.The 1H NMR spectra of the two diastereoisomers differ mainly in the chemical shift of H-2' of the side chain.At first sight the 1H NMR spectra do not allow a stereospecific assignment.It was found, however, that the NOE between the anomeric proton H-1 and H-2' of the side chain is considerably larger in epi-heterodendrin than in heterodendrin, which indicates on a time-averaged basis a smallerdistance between these two protons in epi-heterodendrin.This difference in conformational behaviour is correctly reproduced by molecular mechanics calculations, thereby offering a method for the discrimination of these two glycosides.Keywords: MM2; Cyanogenic glycoside; 3D structure; Conformational analysis; Glucosidase
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