Journal of Asian Natural Products Research p. 724 - 729 (2014)
Update date:2022-08-18
Topics:
Gao, Yan-Ping
Shen, Yun-Heng
Xu, Xi-Ke
Tian, Jun-Mian
Zeng, Hua-Wu
Lin, Sheng
Liu, Chun-Mei
Zhang, Wei-Dong
Two new lignans, 9-salicyl-(+)-isolariciresinol (1) and gaultheroside G (2), together with seven known compounds, were isolated from the ethanolic extract of the whole plant of Gaultheria yunnanensis. Their structures were determined by extensive NMR and MS analyses. Gaultheroside G (2) was found to have an unusual ether linkage between the 2 and 9′ positions of aryl-tetralin lignan skeleton. All nine compounds were assayed for inhibitory effects against nitric oxide and pro-inflammatory cytokines TNF- and IL-6 release in LPS-induced RAW 246.7 macrophages, while no significant activities were observed for the evaluated compounds. 2014
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