Journal of Asian Natural Products Research p. 1056 - 1060 (2011)
Update date:2022-08-16
Topics:
Nazir, Mamona
Sultan, Misbah
Riaz, Naheed
Hafeez, Maria
Hussain, Hidayat
Ahmed, Ishtiaq
Schulz, Barbara
Draeger, Siegfried
Jabbar, Abdul
Krohn, Karsten
Ashraf, Muhammad
Saleem, Muhammad
Chromatographic purification of the extract of an endophytic fungal culture yielded depsitinuside (1), a new phenolic ester together with ergosterol (2) and (22E,24S)-24-methyl-5-a-cholesta-7,22-diene-3b,5,6b-triol (3). The structure of 1 was elucidated based on 1D, 2D NMR spectroscopy and high-resolution mass spectrometry, whereas the known compounds (2 and 3) were identified by 1H NMR, mass spectrometry, and in comparison with the literature values. Compound 1 was evaluated for its enzyme inhibitory potential against acetylcholinesterase, butyrylcholinesterase and lipoxygenase, and was found inactive (10%-40% inhibition at a concentration of 2 mg/ml).
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