Synthesis p. 1065 - 1067 (1986)
Update date:2022-08-25
Topics:
Karimian, Khashayar
Mohanazadeh, Farajollah
A convenient and efficient method for the quaternization at N-1' of thiamin and 2-(1-hydroxyethyl)-thiamin with various alkyl halides and benzyl bromide is presented.Quaternization of 2-(1-ethoxycarbonyl-1-hydroxyethyl)-thiamin was unsuccessful, resulting in the release of ethyl pyruvate and the formation of quaternized thiamin.The N-1'-derivatized thiaminium salts were found to possess drastically different physical properties as compared to their parent heterocycles.
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