Organic Letters
Letter
Nishi, M.; Kanai, M. A meta-Selective C−H Borylation Directed by a
Secondary Interaction between Ligand and Substrate. Nat. Chem.
2015, 7, 712−717.
(6) Leow, D.; Li, G.; Mei, T.-S.; Yu, J.-Q. Activation of Remote
meta-C−H Bonds Assisted by an End-on Template. Nature 2012,
486, 518−522.
AUTHOR INFORMATION
Corresponding Authors
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ORCID
(7) (a) Bera, M.; Modak, A.; Patra, T.; Maji, A.; Maiti, D. Meta-
Selective Arene C−H Bond Olefination of Arylacetic Acid Using a
Nitrile-Based Directing Group. Org. Lett. 2014, 16, 5760−5763.
(b) Bera, M.; Maji, A.; Sahoo, S. K.; Maiti, D. Palladium(II)-
Catalyzed meta-C-H Olefination: Constructing Multisubstituted
Arenes through Homo-Diolefination and Sequential Hetero-Diolefi-
nation. Angew. Chem., Int. Ed. 2015, 54, 8515−8519. (c) Bera, M.;
Sahoo, S. K.; Maiti, D. Room-Temperature meta-Functionalization:
Pd(II)-Catalyzed Synthesis of 1,3,5-Trialkenyl Arene and meta-
Hydroxylated Olefin. ACS Catal. 2016, 6, 3575−3579. (d) Maji, A.;
Bhaskararao, B.; Singha, S.; Sunoj, R. B.; Maiti, D. Directing Group
Assisted meta-Hydroxylation by C−H Activation. Chem. Sci. 2016, 7,
3147−3153. (e) Bag, S.; Jayarajan, R.; Dutta, U.; Chowdhury, R.;
Mondal, R.; Maiti, D. Remote meta-C−H Cyanation of Arenes
Enabled by a Pyrimidine-Based Auxiliary. Angew. Chem., Int. Ed. 2017,
56, 12538−12542. (f) Bera, M.; Agasti, S.; Chowdhury, R.; Mondal,
R.; Pal, D.; Maiti, D. Rhodium-Catalyzed meta-C−H Functionaliza-
tion of Arenes. Angew. Chem., Int. Ed. 2017, 56, 5272−5276.
(8) (a) Bag, S.; Patra, T.; Modak, A.; Deb, A.; Maity, S.; Dutta, U.;
Dey, A.; Kancherla, R.; Maji, A.; Hazra, A.; Bera, M.; Maiti, D.
Remote para-C−H Functionalization of Arenes by a D-Shaped
Biphenyl Template-Based Assembly. J. Am. Chem. Soc. 2015, 137,
11888−11891. (b) Maji, A.; Guin, S.; Feng, S.; Dahiya, A.; Singh, V.
K.; Liu, P.; Maiti, D. Experimental and Computational Exploration of
para-Selective Silylation with a Hydrogen-Bonded Template. Angew.
Chem., Int. Ed. 2017, 56, 14903−14907.
Author Contributions
∥M.L. and M.S. contributed equally to this work.
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
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We gratefully acknowledge the Shanghai Institute of Materia
Medica and the Shanghai Institute of Organic Chemistry,
Chinese Academy of Sciences, NSFC (21472211, 21502212,
21772211), the Youth Innovation Promotion Association CAS
(NO. 2014229 and 2018293), the Institutes for Drug
Discovery and Development, the Chinese Academy of Sciences
(NO.CASIMM0120163006), and the Science and Technology
Commission of Shanghai Municipality (17JC1405000) for
financial support. We gratefully acknowledge NSF under the
CCI Center for Selective C−H Functionalization, CHE-
1205646 for financial support.
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