Natural Product Research p. 1845 - 1852 (2020)
Update date:2022-08-11
Topics:
Shamraiz, Umair
Hussain, Hidayat
Ur Rehman, Najeeb
Al-Shidhani, Sulaiman
Saeed, Aasim
Khan, Husain Yar
Khan, Ajmal
Fischer, Lucie
Csuk, René
Badshah, Amin
Al-Rawahi, Ahmed
Hussain, Javid
Al-Harrasi, Ahmed
In the current investigation, a series of heterocyclic derivatives of boswellic acids were prepared along with new monomers of 3-O-acetyl-11-keto-β-boswellic acid (AKBA, 1) 11-keto-β-boswellic acid (KBA, 2) and several new bis-AKBA and KBA homodimers and AKBA-KBA heterodimers. The effects of these compounds on the proliferation of different human cancer cell lines, viz., FaDu (pharynx carcinoma), A2780 (ovarian carcinoma), HT29 (colon adenocarcinoma), and A375 (malignant melanoma), have been evaluated. Thus, KBA homodimer 21 effectively inhibited the growth of FaDu, A2780, HT29, and A375 cells with EC50 values below 9 μM. In addition, compounds 7, 8, 11, 12, 15, 16, and 17 also exhibited cytotoxic effects for A2780, HT29, and A375 cancer cells. In particular, the pyrazine analog 8 was highly cytotoxic for A375 cancer cells with an EC50 value of 2.1 μM.
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