Journal of Medicinal Chemistry p. 544 - 548 (1983)
Update date:2022-08-11
Topics:
Lin
Mancini
Several new 3'-azido and 3'-amino nucleosides (8, 9, 12, and 13) have been synthesized and their biological activities evaluated. Among them, 3'-amino-2',3'-dideoxycytidine (13) was found to exhibit potent cytotoxic activity against both L1210 and S-180 cells in vitro with an ID50 of 0.7 and 4.0 μM, respectively. Furthermore, 13 has also shown antitumor activity against L1210 tumor bearing mice with a T/C x 100 value of 283.
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Doi:10.1021/ja00881a006
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(1999)Doi:10.1016/S0040-4039(97)01574-8
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