the mean and standard deviation. All statistical analyses were
performed using Student’s t-test. Probability values less than 0.05
(P<0.05) were considered to be indicative of statistical significance.
F. Yamashita and M. Hashida, J. Controlled Release, 2007, 118, 262;
(e) M. Elfinger, C. Maucksch and C. Rudolph, Biomaterials, 2007, 28,
3448; (f) S. Fumoto, S. Kawakami, Y. Ito, K. Shigeta, F. Yamashita and
M. Hashida, Mol. Ther., 2004, 10, 719.
6 (a) O. H. Laitinen, H. R. Nordlund, V. P. Hytonen and M. S. Kulomaa,
Trends Biotechnol., 2007, 25, 269; (b) M. Mamede, T. Saga, T. Ishimori,
T. Higashi, N. Sato, H. Kobayashi, M. W. Brechbiel and J. Konishi,
J. Controlled Release, 2004, 95, 133; (c) H. Sakahara and T. Saga, Adv.
Drug Delivery Rev., 1999, 37, 89; (d) H. Huang, S. Oizumi, N. Kojima,
T. Niino and Y. Sakai, Biomaterials, 2007, 28, 3815; (e) M. S. Kim,
K. S. Seo, G. Khang and H. B. Lee, Langmuir, 2005, 21, 4066.
7 (a) R. J. DeLange, J. Biol. Chem., 1970, 245, 907; (b) B. Schechter, R.
Silberman, R. Arnon and M. Wilchek, Eur. J. Biochem., 1990, 189, 327;
(c) L. Chen, B. Schechter, R. Arnon and M. Wilchek, Drug Dev. Res.,
2000, 50, 258.
Acknowledgements
Acknowledgement is made to National Natural Science Founda-
tion of China (50633020), National Key Basic Research Program
of China (2005CB623903) and Ministry of Education of China
(Cultivation Fund of Key Scientific and Technical Innovation
Project 707043).
8 R. Hernandez-Alcoceba, B. Sangro and J. Prieto, Annals of Hepatology,
2007, 6, 5.
References
9 (a) J. M. Llovet, A. Burroughs and J. Bruix, Lancet, 2003, 362, 1907;
(b) A. Follenzi and S. Gupta, J. Hepatol., 2004, 40, 337; (c) M. J.
Willhauck, B. R. Sharif Samani, K. Klutz, N. Cengic, I. Wolf, L. Mohr,
M. Geissler, R. Senekowitsch-Schmidtke, B. Goke, J. C. Morris and C.
Spitzweg, Gene Ther., 2008, 15, 214; (d) V. Schmitz, C. Qian, J. Ruiz, B.
Sangro, I. Melero and G. Mazzolini, Gut, 2002, 50, 130.
10 (a) H. L. Jiang, J. T. Kwon, Y. K. Kim, E. M. Kim, R. Arote, H. J.
Jeong, J. W. Nah, Y. J. Choi and T. Akaike, Gene Ther., 2007, 14, 1389;
(b) C. M. Varga, N. C. Tedford, M. Thomas, A. M. Klibanov, L. G.
Griffith and D. A. Lauffenburger, Gene Ther., 2005, 12, 1023; (c) L.
Liu, M. A. Zern, M. E. Lizarzaburu, M. H. Nantz and J. Wu, Gene
Ther., 2003, 10, 180.
1 (a) S. Li and L. Huang, Gene Ther., 2000, 7, 31; (b) T. Niidome and L.
Huang, Gene Ther., 2002, 9, 1647; (c) Y. Kaneda and Y. Tabata, Cancer
Sci., 2006, 97, 348.
2 (a) H. H. Ahn, J. H. Lee, K. S. Kim, J. Y. Lee, M. S. Kim, G. Khang,
I. W. Lee and H. B. Lee, Biomaterials, 2008, 29, 2415; (b) W. T. Godbey,
K. K. Wu and A. G. Mikos, J. Controlled Release, 1999, 60, 149; (c) U.
Lungwitz, M. Breunig, T. Blunk and A. Gopferich, Eur. J. Pharm.
Biopharm., 2005, 60, 247.
3 (a) C. H. Ahn, S. Y. Chae, Y. H. Bae and S. W. Kim, J. Controlled
Release, 2002, 80, 273; (b) R. Arote, T. H. Kim, Y. K. Kim, S. K.
Hwang, H. L. Jiang, H. H. Song, J. W. Nah, M. H. Cho and C. S. Cho,
Biomaterials, 2007, 28, 735.
4 Y. X. Sun, X. Zeng, Q. F. Meng, X. Z. Zhang, S. X. Cheng and R. X.
Zhuo, Biomaterials, 2008, 29, 4356.
11 J. K. Oh, D. J. Siegwart, H. Lee, G. Sherwood, L. Peteanu, J. O.
Hollinger, K. Kataoka and K. Matyjaszewski, J. Am. Chem. Soc., 2007,
129, 5939.
5 (a) D. A. Wall and A. L. Hubbard, J. Cell Biol., 1985, 101, 2104;
(b) H. Li and Z. M. Qian, Med. Res. Rev., 2002, 22, 225; (c) J. M.
Benns, R. I. Mahato and S. W. Kim, J. Controlled Release, 2002, 79,
255; (d) K. Shigeta, S. Kawakami, Y. Higuchi, T. Okuda, H. Yagi,
12 E. Emilitri, E. Ranucci and P. Ferruti, J. Polym. Sci., Part A: Polym.
Chem., 2005, 43, 1404.
13 J. M. Benns, J. S. Choi, R. I. Mahato, J. S. Park and S. W. Kim,
Bioconjugate Chem., 2000, 11, 637.
4210 | Org. Biomol. Chem., 2009, 7, 4201–4210
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