Journal of Agricultural and Food Chemistry (2019)
Update date:2022-08-18
Topics:
Zhang, Pengfei
Guan, Aiying
Xia, Xiaoli
Sun, Xufeng
Wei, Siyuan
Yang, Jinlong
Wang, Junfeng
Li, Zhinian
Lan, Jie
Liu, Changling
To explore a novel fungicide effectively against cucumber downy mildew (CDM), a series of new arylpyrazole containing pyrimidine ether derivatives were designed and synthesized by employing the intermediate derivatization method (IDM). The structures of synthesized compounds were identified by 1H NMR, 13C NMR, elemental analyses, MS, and X-ray diffraction. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activities against CDM. Especially, compound 7 (EC50 = 1.22 mg/L) displayed significantly higher bioactivity than that of commercial fungicides diflumetorim and flumorph and nearly equal effect to that of cyazofamid. The relationship between the structure and fungicidal activity of the synthesized compounds was discussed as well. The study showed that compound 7 was a promising fungicide candidate for further development.
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