Journal of Asian Natural Products Research
3
Table 2. 1H NMR spectral data of target compounds.
Compound 1H NMR (CDCl3)
I1
d 11.0 (s, 1H, COOH), 5.35–5.29 (m, 1H, H-12), 2.26 (d, J ¼ 8.6 Hz, 1H, H-18), 2.18
(s, 3H, CH3COON), 1.38–1.34 (m, 1H, H-19), 1.32–1.29 (m, 1H, H-20), 1.27 (t,
J ¼ 7.5 Hz, 1H, H-5), 1.20 (t, J ¼ 7.3 Hz, 1H, H-9), 1.15 (s, 3H, CH3), 1.12 (s, 3H,
CH3), 1.05 (s, 3H, CH3), 0.96 (s, 3H, CH3), 0.89 (d, J ¼ 7.0 Hz, 3H, CH3), 0.85 (d,
J ¼ 7.1 Hz, 3H, CH3), 0.79 (s, 3H, CH3)
I2
d 5.33 (t, J ¼ 3.5 Hz, 1H, H-12), 3.66 (t, J ¼ 8.5 Hz, 2H, NCH2CH2aO), 3.62 (t,
J ¼ 8.5 Hz, 2H, NCH2CH2bO), 3.48 (t, J ¼ 8.0 Hz, 2H, NCH2aCH2O), 3.41 (t,
J ¼ 8.0 Hz, 2H, NCH2bCH2O), 3.00 (d, J ¼ 7.5 Hz, 1H, H-18), 2.15 (s, 3H,
CH3COON), 1.41–1.39 (m, 1H, H-19), 1.37–1.33 (m, 1H, H-20), 1.28 (t, J ¼ 7.5 Hz,
1H, H-5), 1.22 (t, J ¼ 7.0 Hz, 1H, H-9), 1.13 (s, 3H, CH3), 1.09 (s, 3H, CH3), 1.04 (s,
3H, CH3), 0.93 (s, 3H, CH3), 0.86 (d, J ¼ 7.5 Hz, 3H, CH3), 0.81 (d, J ¼ 7.0 Hz, 3H,
CH3), 0.77 (s, 3H, CH3)
I3
d 8.51 (s, 1H, NH), 7.53–7.21 (m, 5H, Ph), 5.31 (t, J ¼ 4.0 Hz, 1H, H-12), 2.43 (d,
J ¼ 8.3 Hz, 1H, H-18), 2.32 (s, 3H, CH3COON), 1.46–1.42 (m, 1H, H-19), 1.38–1.35
(m, 1H, H-20), 1.30 (t, J ¼ 7.0 Hz, 1H, H-5), 1.23 (t, J ¼ 7.1 Hz, 1H, H-9), 1.10 (s, 3H,
CH3), 1.06 (s, 3H, CH3), 1.02 (s, 3H, CH3), 0.95 (s, 3H, CH3), 0.89 (d, J ¼ 7.5 Hz, 3H,
CH3), 0.83 (d, J ¼ 7.0 Hz, 3H, CH3), 0.76 (s, 3H, CH3)
I4
d 8.62 (s, 1H, NH), 7.68–7.26 (m, 4H, Ph), 5.34 (t, J ¼ 3.6 Hz, 1H, H-12), 5.27 (s, 1H,
OH), 4.64 (s, 2H, CH2OH), 2.50 (d, J ¼ 7.6 Hz, 1H, H-18), 2.21 (s, 3H, CH3COON),
1.43–1.40 (m, 1H, H-19), 1.38–1.35 (m, 1H, H-20), 1.26 (t, J ¼ 7.5 Hz, 1H, H-5), 1.21
(t, J ¼ 7.0 Hz, 1H, H-9), 1.08 (s, 3H, CH3), 1.01 (s, 3H, CH3), 0.95 (s, 3H, CH3), 0.89 (s,
3H, CH3), 0.85 (d, J ¼ 8.1 Hz, 3H, CH3), 0.80 (d, J ¼ 7.5 Hz, 3H, CH3), 0.75 (s, 3H,
CH3)
I5
d 7.52–7.21 (m, 5H, Ph), 5.29 (t, J ¼ 3.6 Hz, 1H, H-12), 4.55 (s, 2H, CH2O), 2.53 (d,
J ¼ 7.5 Hz, 1H, H-18), 2.20 (s, 3H, CH3COON), 1.44–1.40 (m, 1H, H-19), 1.36–1.33
(m, 1H, H-20), 1.24 (t, J ¼ 7.0 Hz, 1H, H-5), 1.18 (t, J ¼ 6.5 Hz, 1H, H-9), 1.10 (s, 3H,
CH3), 1.05 (s, 3H, CH3), 0.93 (s, 3H, CH3), 0.87 (s, 3H, CH3), 0.83 (d, J ¼ 7.5 Hz, 3H,
CH3), 0.79 (d, J ¼ 7.5 Hz, 3H, CH3), 0.72 (s, 3H, CH3)
II1
II2
d 9.68 (s, 1H, CHO), 5.33 (t, J ¼ 3.1 Hz, 1H, H-12), 3.76 (s, 3H, COOCH3), 3.10 (t,
J ¼ 7.0 Hz, 1H, H-2), 2.52 (d, J ¼ 6.0 Hz, 1H, H-18), 1.42–1.38 (m, 1H, H-19), 1.32–
1.29 (m, 1H, H-20), 1.21 (t, J ¼ 6.2 Hz, 1H, H-5), 1.15 (t, J ¼ 7.8 Hz, 1H, H-9), 1.08 (s,
3H, CH3), 1.03 (s, 3H, CH3), 0.98 (s, 3H, CH3), 0.95 (s, 3H, CH3), 0.88 (d, J ¼ 6.5 Hz,
3H, CH3), 0.83 (d, J ¼ 7.1 Hz, 3H, CH3), 0.77 (s, 3H, CH3)
d 9.66 (s, 1H, CHO), 5.31 (t, J ¼ 3.5 Hz, 1H, H-12), 4.08–4.05 (m, 2H, COOCH2CH3),
3.12 (t, J ¼ 7.0 Hz, 1H, H-2), 2.50 (d, J ¼ 7.0 Hz, 1H, H-18), 1.48–1.44 (m, 1H, H-19),
1.35–1.32 (m, 1H, H-20), 1.25 (t, J ¼ 8.7 Hz, 3H, COOCH2CH3), 1.20 (t, J ¼ 6.5 Hz,
1H, H-5), 1.13 (t, J ¼ 7.0 Hz, 1H, H-9), 1.06 (s, 3H, CH3), 1.01 (s, 3H, CH3), 0.97 (s,
3H, CH3), 0.93 (s, 3H, CH3), 0.86 (d, J ¼ 7.5 Hz, 3H, CH3), 0.82 (d, J ¼ 8.0 Hz, 3H,
CH3), 0.75 (s, 3H, CH3)
II3
d 9.68 (s, 1H, CHO), 5.32 (t, J ¼ 3.5 Hz, 1H, H-12), 4.24–4.21 (m, 1H, COOCH), 3.11
(t, J ¼ 7.0 HZ, 1H, H-2), 2.52 (d, J ¼ 6.5 Hz, 1H, H-18), 1.50–1.47 (m, 1H, H-19),
1.44–1.41 (m, 1H, H-20), 1.20 (d, J ¼ 8.0 Hz, 3H, COOCH(CH3a)2), 1.17 (d,
J ¼ 8.0 Hz, 3H, COOCH(CH3b)2), 1.14 (t, J ¼ 7.3 Hz, 1H, H-5), 1.10 (t, J ¼ 7.0 Hz,
1H, H-9), 1.05 (s, 3H, CH3), 1.01 (s, 3H, CH3), 0.95 (s, 3H, CH3), 0.91 (s, 3H, CH3),
0.87 (d, J ¼ 7.5 Hz, 3H, CH3), 0.80 (d, J ¼ 8.0 Hz, 3H, CH3), 0.73 (s, 3H, CH3)
d 9.67 (s, 1H, CHO), 5.30 (t, J ¼ 3.5 Hz, 1H, H-12), 3.65 (t, J ¼ 8.5 Hz, 2H,
NCH2CH2aO), 3.62 (t, J ¼ 8.5 Hz, 2H, NCH2CH2bO), 3.50 (t, J ¼ 8.0 Hz, 2H,
NCH2aCH2O), 3.46 (t, J ¼ 8.0 Hz, 2H, NCH2bCH2O), 3.10 (t, J ¼ 7.0 HZ, 1H, H-2),
2.50 (d, J ¼ 7.5 Hz, 1H, H-18), 1.51–1.48 (m, 1H, H-19), 1.46–1.42 (m, 1H, H-20),
1.19 (t, J ¼ 8.0 Hz, 1H, H-5), 1.13 (t, J ¼ 7.0 Hz, 1H, H-9), 1.09 (s, 3H, CH3), 1.04 (s,
3H, CH3), 0.93 (s, 3H, CH3), 0.88 (s, 3H, CH3), 0.85 (d, J ¼ 7.0 Hz, 3H, CH3), 0.81 (d,
J ¼ 8.0 Hz, 3H, CH3), 0.74 (s, 3H, CH3)
II4
(Continued)