Journal of Medicinal Chemistry p. 398 - 400 (1978)
Update date:2022-08-22
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Iijima,I. et al.
(+)-Naloxone was prepared in 26% overall yield in eight steps from (+)-7-bromodihydrocodeinone dimethyl ketal by a synthesis which excluded enantiomeric contamination. (+)-Naloxone was examined in three assay systems and found to have no more than 1/1000(-1)/10 000th the activity of (-)-naloxone; it can, thus, serve to test the stereospecificity of the biochemical and pharmacological actions of (-)-naloxone.
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Doi:10.1007/BF00960641
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(2020)Doi:10.3762/bjoc.13.185
(2017)Doi:10.1016/j.saa.2016.10.004
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