Bioorganic and Medicinal Chemistry Letters p. 1573 - 1575 (2004)
Update date:2022-08-11
Topics:
Miranda
Marinho, Bruno G.
Leit?o, Suzana G.
Matheus, Maria Eline
Fernandes, Patrícia D.
Vasconcellos
We described in this paper the first synthesis to the (±) cis (6-ethyl-tetrahydropyran-2-yl) formic acid (1) using the very efficient Prins cyclization reaction as strategy to construction of its tetrahydropyran skeleton. This new compound presented a significant antinociceptive property by the tail-flick model.
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