Bulletin of the Chemical Society of Japan p. 2592 - 2593 (1980)
Update date:2022-08-11
Topics:
Ozawa, Yoichi
Tsuji, Toshiaki
Ariyoshi, Yasuo
A convenient synthesis of glutathione (GSH) by the use of minimal protecting groups was investigated.N-Formyl-L-2-amino-4-cyanobutyric acid ethyl ester was condensed with ethyl L-cysteinylglycinate to give (4R)-2-<(3S)-3-ethoxycarbonyl-3-(formylamino)propyl>-4-(ethoxycarbonylmethylcarbamoyl)-2-thiazoline.This compound was saponified in aqueous acetone at -15- -20 deg C and subsequently treated with dilute H2SO4 (pH 4) to yield formylglutathione, whose formyl group was then hydrolyzed with 0.5 M (1M = 1 mol dm-3) H2SO4 to give free GSH.For purification, this was changed to a copper thiolate, which was then decomposed with H2S to afford pure GSH.
View MoreZHEJIANG JIANYE CHEMICAL CO.,LTD.
Contact:86-571-64149273,64149234
Address:No. 48, Fuxi Road, Meicheng Town
Contact:13813902930 025-52714267
Address:20 Fengji Road, Yuhua Economic Development Zone, Nanjing, Jiangsu, P. R. China
Contact:086-027-83820093
Address:16#luojiashan, wuchang district
TAIZHOU XINGCHENG CHEMPHARM CO.,LTD.
Contact:0086-0576-88551200,88886292 ,88880039
Address:B Area. 10 Floor.Yaodadasha. 289#.Shifu Road.Taizhou.Zhejiang.China
Contact:+86-731-84427351
Address:154 JIANXIANG SOUTH ROAD
Doi:10.1016/j.cattod.2014.08.019
(2015)Doi:10.1248/cpb.40.2540
(1992)Doi:10.1055/s-0037-1610304
(2019)Doi:10.1021/jm0580297
(2006)Doi:10.1021/acs.organomet.0c00533
(2020)Doi:10.1007/s00044-017-2045-0
(2018)