Nucleosides and Nucleotides p. 245 - 254 (1994)
Update date:2022-08-17
Topics:
Lin
Luo
Liu
Syntheses of 1-[cis-2-hydroxy-cis-3-(hydroxymethyl)cyclobutyl]thymine (1) and related compounds by a novel method are reported. Coupling of 3- benzyloxymethyl-1-cyclobutene (2) with silylated thymine in the presence of NIS, followed by treatment with DBU, basic hydrolysis and catalytic hydrogenation produced the target compound (1) and its isomer (12).
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