Phosphorus, Sulfur and Silicon and the Related Elements p. 2607 - 2616 (2005)
Update date:2022-08-11
Topics:
Liu, Xue-Jun
Chen, Ru-Yu
Bai, Dong-Lu
A series of novel 2-(thymin-1′-ylmethoxy)ethyl alkyl sulfides have been synthesized in three steps from thymine. They have been oxidized into sulfoxide and sulfone derivatives by means of NaIO4 and H 2O2 30%/diethyl azodicarboxylate (DEAD), respectively, in high yields. All products were characterized by 1H NMR and IR spectra and elemental analyses. The preliminary bioassay indicates that the compound 6g exhibited potential antitumor activity. Copyright Taylor & Francis Inc.
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