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RSC Advances
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COMMUNICATION
Journal Name
Conclusions
Chinese Traditional Medicine (ZhonDgOIY: 1a0o.10D39a/C5CRiA2D2i1a4n5)E,
Shanghai Science and Technology Press, Shanghai, 2006, pp.
3028.
In summary, our bioassay guided investigation into the
chemistry of the traditional Chinese medicinal plant
Chloranthus japonicus led to the discovery of chlojapolactone
13. (a) J. Y. Zhu, B. Cheng, Y. J. Zheng, Z. Dong, S. L. Lin, G. H.
Tang, Q. Gu and S. Yin, RSC Adv., 2015, 5, 12202. (b) Z. Dong,
A (1), a novel lindenane dimer featuring a rare 1,3-dioxolane
Q. Gu, B. Cheng, Z. B. Cheng, G. H. Tang, Z. H. Sun, J. S.
Zhang, J. M. Bao and S. Yin, RSC Adv., 2014, , 55036.
linkage between a 8,9-seco lindenane and a lindenane
sesquiterpenoid. To the best of our knowledge, dimers
incorporating a 1,3-dioxolane linkage are rare in nature,
known examples of which are limited to the sesquiterpene
dimers volvalerelactone B from Valeriana officinalis var.
latifolia21 and cinnafragrin A and B and capsicodendrin from
Cinnamosma fragrans.22 Lindenane-type dimers reported
previously were exclusively formed through direct carbon-
carbon coupling of two monomers. Chlojapolactone
comprising a rare 8,9-seco-lindenane unit represented the first
example of lindenane dimer coupled via an acetal bridge. A
plausible biosynthetic route for
mimicked by biomimetic semisynthesis. Compound
potential inhibitory effects on nitric oxide (NO) production
induced by lipopolysaccharide (LPS) in RAW 264.7 cells, which
may account for the inhibitory effect of the crude extract and
explain the anti-inflammatory function of C. japonicus in folk
medicine. Further studies of compound
on other anti-inflammatory signal pathways are under
4
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A
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1
was proposed and partially
exhibited
Cuong, C. P. Van and D. V. Ca, Lett. Org. Chem., 2014, 11
639.
,
1
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,
1193.
1 regarding its effects
23. Chlojapolactone A (
1
)
.
colorless oil; 20
67.20 (c 0.1,
D
CHCl3); UV (MeOH) max (log
1751, 1711, 1648, 1080, 960 cm ; 1H and 13C NMR data,
see Table 1 and ESI Table S1;† positive ESIMS m/z 559.3
Na , negative ESIMS m/z 535.5 [M H]; HRESIMS m/z
535.2331 [M
H] (calcd for C31H35O8, 535.2337).
) 223 (4.20) nm; IR (KBr) max
1
investigation.
M
Acknowledgments
The authors thank the National High Technology Research and
Development Program of China (863 Project, No. 2015AA020928),
the Guangdong Natural Science Funds for Distinguished Young
Scholar (No. 2014A030306047), and the National Natural Science
Foundation of China (No. 81402813) for providing financial support
to this work.
Notes and references
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4 | J. Name., 2012, 00, 1-3
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