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ChemComm
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COMMUNICATION
ChemComm
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Camb)., 2017, 53, 2443-2446; (b) H. Li, W. Liu, F. Zhang, X.
(
DOI: 10.1039/C9CC04714J
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Fig. 5 Representative fluorescence images of BALB/c mouse (pseudocolor).
The mouse received an intravenous injection of probe 1 (1 mM, 100 μL) at
different times (0, 60, 90, 120, 180 min). The second group of mouse was
pretreated with kojic acid (1 mM, 100 μL) for 60 min, and followed by
injection of probe 1 (1 mM, 100 μL) into the same region at different times (0,
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(a) Z. Li, Y. F. Wang, X. Zhang, C. Zeng, L. Hu and X. J.
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0, 90, 120, 180 min).
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909; (c) T. I. Kim, J. Park, S. Park, Y. Choi and Y. Kim,
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fluorescence intensity of the mouse pretreated with kojic acid and
then injected with probe 1 was significantly weak, indicating that
kojic acid effectively inhibited TYR. In vivo TYR imaging may be a
promising method for early detection of malignant melanoma.
In summary, this paper reviews the synthesis of near-infrared
fluorescent probes and their excellent properties, as well as their
application in zebrafish in vivo and in vitro living cell imaging. The
probe connected a new water-soluble fluorophore with a recognition
group that could avoid ROS interference and specifically recognize
TYR. The probe is highly stable over physiological temperature and
pH ranges and is capable of accurately detecting TYR in biological
systems without interference from ubiquitous entities. Especially, the
probe has been successfully applied to the diagnosis of melanoma in
a xenogeneic mouse model. It demonstrates favorable characteristics
in terms of low toxicity, high specificity, high sensitivity, stable
photo-stability. The superior properties of the probe make it of great
potential use in other biosystems and in vivo imaging studies.
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Conflicts of interest
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There are no conflicts to declare.
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Acknowledgements
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We are grateful to the financial support from the National Natural
Science Foundation of China (Nos.21605099), the Fundamental
Research Funds for the Central Universities, China (GK201802019),
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721-2724.
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Innovation and Key Project (2018NY-099). Financial support from
the Young Talent Fund of University Association for Science and
Technology in Shaanxi, China (20180207) is also greatly
appreciated.
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