Bioorganic and Medicinal Chemistry Letters p. 3375 - 3380 (1999)
Update date:2022-08-18
Topics:
Xu, Wei
Huang, Liang-Fu
Bauer, Ludwig
Bhargava, Hemendra N.
Dunn III, William J.
A class of opioid receptor active derivatives of oxymorphone has been synthesized using a common enaminone intermediate. The derivatives have heterocyclic groups fused to the 6,7-positions of the morphinan system and all were synthesized in high yield. A pyrazolo derivative is an agonist for the μ and δ receptors and an antagonist for the κ receptor.
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