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Chemical Science
Page 8 of 10
DOI: 10.1039/C9SC02765C
ARTICLE
Journal Name
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6, 67
additive in many foods and drinks,
demonstrates a 13. I. V. Koptyug, K. V. Kovtunov, S. R. Burt, M. S. Anwar, C. Hilty,
potential role for SABRE-Relay in the detection of important S.-I. Han, A. Pines and R. Z. Sagdeev, J. Am. Chem. Soc., 2007,
low concentration analytes. 129, 5580-5586.
Given the ubiquitous nature of alcohols throughout 14. S. B. Duckett and N. J. Wood, Coord. Chem. Rev., 2008, 252
,
chemical and biochemical literature, the results reported here 2278-2291.
could lead to the ability to gain further mechanistic insight into 15. C. Godard, J. Lopez-Serrano, M. D. Galvez-Lopez, M. Rosello-
their reactivity by allowing the detection of low concentration Merino, S. B. Duckett, I. Khazal, A. Lledos and A. C. Whitwood,
species, whether as contaminants or intermediates. Finally, as Magn. Reson. Chem., 2008, 46, S107-S114.
the SABRE-Relay process expands the number of substrates 16. C. Godard, S. B. Duckett, S. Polas, R. Tooze and A. C.
2
amenable to p-H based polarisation this study may be useful Whitwood, Dalton Trans., 2009, 2496-2509.
in identifying a pathway to determine optimal conditions for 17. O. Torres, B. Procacci, M. E. Halse, R. W. Adams, D. Blazina, S.
the polarization of other functional groups.
B. Duckett, B. Eguillor, R. A. Green, R. N. Perutz and D. C.
Williamson, J. Am. Chem. Soc., 2014, 136, 10124-10131.
1
8. F. Dalitz, M. Cudaj, M. Maiwald and G. Guthausen, Prog.
Conflicts of interest
There are no conflicts to declare.
Nucl. Magn. Reson. Spectrosc., 2012, 60, 52-70.
19. S. A. Colebrooke, S. B. Duckett, J. A. B. Lohman and R.
Eisenberg, Chem. - Eur. J., 2004, 10, 2459-2474.
2
0. L. S. Lloyd, R. W. Adams, M. Bernstein, S. Coombes, S. B.
Acknowledgements
This work was supported by The Wellcome Trust (Grants
Duckett, G. G. R. Green, R. J. Lewis, R. E. Mewis and C. J. Sleigh, J.
Am. Chem. Soc., 2012, 134, 12904-12907.
2
1. N. Eshuis, N. Hermkens, B. J. A. van Weerdenburg, M. C.
092506 and 098335), the EPSRC (EP/R51181X/1 and B.J.T
Feiters, F. P. J. T. Rutjes, S. S. Wijmenga and M. Tessari, J. Am.
Chem. Soc., 2014, 136, 2695-2698.
studentship) and the University of York.
2
2. K. V. Kovtunov, E. V. Pokochueva, O. G. Salnikov, S. F. Cousin,
D. Kurzbach, B. Vuichoud, S. Jannin, E. Y. Chekmenev, B. M.
Goodson, D. A. Barskiy and I. V. Koptyug, Chem. Asian J., 2018,
13, 1857-1871.
23. T. C. Eisenschmid, R. U. Kirss, P. P. Deutsch, S. I. Hommeltoft,
R. Eisenberg, J. Bargon, R. G. Lawler and A. L. Balch, J. Am. Chem.
Soc., 1987, 109, 8089-8091.
Notes and references
1
2
2
. T. H. Witney, M. I. Kettunen and K. M. Brindle, J. Biol. Chem.,
011, 286, 24572-24580.
. H. Gutte, A. E. Hansen, H. H. Johannesen, A. E. Clemmensen,
J. H. Ardenkjar-Larsen, C. H. Nielsen and A. Kjar, Am J Nucl Med
Mol Imaging, 2015, , 548-560.
5
24. J. Colell, P. Türschmann, S. Glöggler, P. Schleker, T. Theis, M.
3
. W. C. Chen, X. Q. Teo, M. Y. Lee, G. K. Radda and P. Lee, NMR Ledbetter, D. Budker, A. Pines, B. Blümich and S. Appelt, Phys.
Biomed., 2015, 28, 1021-1030.
. T. B. Rodrigues, E. M. Serrao, B. W. C. Kennedy, D.-E. Hu, M.
I. Kettunen and K. M. Brindle, Nat. Med., 2013, 20, 93.
Rev. Lett., 2013, 110, 137602.
25. M. G. Pravica and D. P. Weitekamp, Chem. Phys. Lett., 1988,
145, 255-258.
4
5
6
. H. T., D. H. and F. L., NMR Biomed., 2013, 26, 1831-1843.
. v. M. Cornelius, L. P. E.Z., H. Simon, K. Kayvan, W. D. M., A. L.
26. F. Reineri, T. Boi and S. Aime, Nat. Commun., 2015, 6, 5858.
27. E. Cavallari, C. Carrera, S. Aime and F. Reineri, Chemistry-A
European Journal, 2017, 23, 1200-1204.
J. Henrik, G. Andrei, B. Robert, K. John and V. D. B., J. Magn.
Reson. Imaging, 2011, 33, 692-697.
28. E. Cavallari, C. Carrera, M. Sorge, G. Bonne, A. Muchir, S.
7
. M. Fuetterer, J. Busch, S. M. Peereboom, C. von Deuster, L.
Aime and F. Reineri, Scientific Reports, 2018, 8, 8366.
Wissmann, M. Lipiski, T. Fleischmann, N. Cesarovic, C. T. Stoeck
and S. Kozerke, J. Cardiovasc. Magn. Reson., 2017, 19, 46.
29. R. W. Adams, J. A. Aguilar, K. D. Atkinson, M. J. Cowley, P. I.
P. Elliott, S. B. Duckett, G. G. R. Green, I. G. Khazal, J. López-
Serrano and D. C. Williamson, Science, 2009, 323, 1708-1711.
8
. P. Nikolaou, A. M. Coffey, L. L. Walkup, B. M. Gust, N.
Whiting, H. Newton, S. Barcus, I. Muradyan, M. Dabaghyan, G. D. 30. P. J. Rayner and S. Duckett, Angew. Chem. Int. Ed., 2018, 57
,
Moroz, M. S. Rosen, S. Patz, M. J. Barlow, E. Y. Chekmenev and
6742-6753.
B. M. Goodson, Proc. Natl. Acad. Sci. U.S.A., 2013, 110, 14150-
31. N. Eshuis, R. L. E. G. Aspers, B. J. A. van Weerdenburg, M. C.
Feiters, F. P. J. T. Rutjes, S. S. Wijmenga and M. Tessari, J. Magn.
Reson., 2016, 265, 59-66.
1
9
4155.
. P. Nikolaou, A. M. Coffey, L. L. Walkup, B. M. Gust, N.
Whiting, H. Newton, I. Muradyan, M. Dabaghyan, K. Ranta, G. D.
Moroz, M. S. Rosen, S. Patz, M. J. Barlow, E. Y. Chekmenev and
B. M. Goodson, Magn. Reson. Imaging, 2014, 32, 541-550.
32. R. W. Adams, S. B. Duckett, R. A. Green, D. C. Williamson and
G. G. R. Green, J. Chem. Phys., 2009, 131, 194505.
33. R. A. Green, R. W. Adams, S. B. Duckett, R. E. Mewis, D. C.
Williamson and G. G. R. Green, Prog. Nucl. Magn. Reson.
Spectrosc., 2012, 67, 1-48.
34. D. A. Barskiy, A. N. Pravdivtsev, K. L. Ivanov, K. V. Kovtunov
and I. V. Koptyug, Phys. Chem. Chem. Phys., 2016, 18, 89-93.
35. S. Knecht, A. N. Pravdivtsev, J.-B. Hovener, A. V. Yurkovskaya
1
2
1
1
1
0. C. R. Bowers and D. P. Weitekamp, Phys. Rev. Lett., 1986, 57
645-2648.
1. C. R. Bowers and D. P. Weitekamp, J. Am. Chem. Soc., 1987,
09, 5541-5542.
2. J. López-Serrano, S. B. Duckett and A. Lledós, J. Am. Chem.
,
Soc., 2006, 128, 9596-9597.
and K. L. Ivanov, RSC Adv., 2016, 6, 24470-24477.
8
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