European Journal of Medicinal Chemistry p. 821 - 824 (1993)
Update date:2022-08-11
Topics:
Courant
Leblois
Le Baut
Venco
Panconi
A series of 6 new N-(pyridin-2-yl)-3-(piperazin-1-yl)propanamides were synthesized from the corresponding N-pyridinylpropenamides to determine potential antiallergic activity as assayed in vivo by the passive cutaneous anaphylaxis test. The IC50 of compound 12 after oral administration was comparable to that of oxatomide.
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