European Journal of Medicinal Chemistry p. 339 - 350 (2019)
Update date:2022-08-29
Topics:
Kaur, Tanpreet
Menon, Arya
Garner, Amanda L.
Eukaryotic translation initiation factor 4E (eIF4E) is a key player in the initiation of cap-dependent translation through recognition of the m7GpppX cap at the 5’ terminus of coding mRNAs. As eIF4E overexpression has been observed in a number of human diseases, most notably cancer, targeting this oncogenic translation initiation factor has emerged as a promising strategy for the development of novel anti-cancer therapeutics. Toward this end, in the present study, we have rationally designed a series of Bn7GxP-based PROTACs for the targeted degradation of eIF4E. Herein we describe our synthetic efforts, in addition to biochemical and cellular characterization of these compounds.
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Doi:10.1021/acs.macromol.5b02501
(2016)Doi:10.1016/0022-328X(94)05293-K
(1995)Doi:10.1002/oms.1210021213
(1969)Doi:10.1016/j.tetlet.2006.02.023
(2006)Doi:10.1039/c4ra06516f
(2014)Doi:10.1039/d0cc03065a
(2020)