Bioorganic and Medicinal Chemistry Letters p. 2613 - 2616 (1997)
Update date:2022-08-17
Topics:
Bystrom, Cory E.
Pettigrew, Donald W.
Remington, S. James
Branchaud, Bruce P.
β,γ-Difluoromethyleneadenosine-5'-triphos (AMP-PCF2P, 3) and γ-arsono-β,γ-methyleneadenosined'-diphosphate (AMP-PCAs, 4) were synthesized and were found to be competitive inhibitors of glycerolkinase. Commercially available AMP-PCP and AMP-PNP also are competitive inhibitors. The structural similarities and differences of these ATP analogs and their effect on kinase inhibition are discussed.
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