270
Glycoconj J (2021) 38:261–271
is in good shape and 98.08 % of total amino acids are observed
in the favored region of the plot (Fig. 4). Molecular docking
showed all the three conjugates have an excellent binding
affinity towards GLUT4. AG2 (Fig. 5) showed hydrogen
bond interaction with ARG169, ARG228, GLU263 aromatic
interactions with TRP404, hydrophobic interactions with
SER153, PRO157, GLY161, GLU162, ARG169, ARG228,
ALA408, MET420. AP2 (Fig. 6) showed hydrogen bond in-
teraction with GLN177, hydrophobic interactions with
SER96, ILE99, SER153, GLY154, PRO157, GLY161,
GLU162, ARG169, ARG228, GLU345, ALA408,
MET420. AC2 (Fig. 7) showed hydrogen bond interaction
with SER153, hydrophobic interactions with SER96, ILE99,
GLY150, SER153, GLY154, PRO157, GLY161, GLU162,
ARG169, ARG228, GLU345, ALA408, MET420.
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1
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Acknowledgements Authors are thankful to the Principal, Ashokrao
Mane College of Pharmacy, Peth Vadgaon, for providing facility to carry
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Mandal’s College of Pharmacy, Solapur and Bharati Vidyapeeth
College of Pharmacy, Kolhapur for supporting this research work.
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Conflicts of interest The authors declare that they have no conflicts of
interest.
Ethical approval This article does not contain any studies with human
participants or animals performed by any of the authors.