Helvetica Chimica Acta p. 478 - 481 (1981)
Update date:2022-08-28
Topics:
Oppolzer, Wolfgang
Francotte, Eric
Baettig, Kurt
(+/-)-Lysergic acid (1) has been synthesized from 4-hydroxymethyl-1-tosylindole (2) by a sequence of 9 steps.The crucial thermolysis 9 ---> 10 involves the in situ-generation of the transient diene III which undergoes an intramolecular cycloaddition to a C,N-double bond at 200 deg C and at low stationary concentration of III.
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