Journal of Fluorine Chemistry p. 265 - 270 (1993)
Update date:2022-08-29
Topics:
Sareen, Vineeta
Jain, Sunita
Six new 3-(4'-fluorophenyl)-1,5-trisubstituted pyrazoles have been synthesized from the appropriate fluorinated 1,3-diketones and pentafluorophenylhydrazine in the presence of absolute ethanol and hydrochloric acid, viz., 1-pentafluorophenyl-3-(4'-fluorophenyl)-5-methylpyrazole, 1-pentafluorophenyl-3-(4'-fluorophenyl-5-trifluoromethylpyrazole, 5-ethyl-1-pentafluorophenyl-3-(4'-fluorophenyl) pyrazole, 5-(pentafluoroethyl)-1-pentafluorophenyl-3-(4'-fluorophenyl) pyrazole, 1-pentafluorophenyl-3-(4'-fluorophenyl 5-n-propylpyrazole and 5-(heptafluoropropyl)-1-pentafluorophenyl-3-(4'-fluorophenyl) pyrazole.In addition, six new 2-amino-4-(4'-fluorophenyl)-6-alkyl(perfluoroalkyl)-trisubstituted pyrimidines have been prepared from the same diketones and guanidine carbonate in the presence of hydrochloric acid using absolute ethanol as a solvent, viz., 2-amino-4-(4'-fluorophenyl)-6-methylpyrimidine., 2-amino-4-(4'-fluorophenyl)-6-trifluoromethylpyrimidine, 2-amino-6-ethyl-4-(4'-fluorophenyl)pyrimidine, 2-amino-6-pentafluoroethyl-4-(4'-fluorophenyl)pyrimidine, 2-amino-4-(4'-fluorophenyl)-6-n-propylpyrimidine and 2-amino-6-(heptafluoropropyl)-4-(4'-fluorophenyl)pyrimidine.All new fluorinated pyrazoles as well as pyrimidines have been characterized by elemental analyses as well as spectral studies.
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